.NET MAUI and React Native are both cross-platform frameworks. Still, they cater to different development needs. .NET MAUI, using C# and XAML, integrates seamlessly with the .NET ecosystem and offers strong native performance by directly accessing platform-specific APIs. It supports mobile platforms like Android and iOS and desktop environments such as macOS and Windows, making it a comprehensive solution for developers targeting both. React Native, on the other hand, is built on JavaScript and React and appeals to web developers transitioning to mobile app development, focusing mainly on mobile platforms. The choice between the two depends on your background and project needs.